Endocrine Abstracts

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The gut microbiota has co-evolved with its mammalian host and is an important factor that contributes to host metabolism. Metagenomic analyses of stool samples from patients have revealed that the gut microbiota is altered in these metabolic diseases and germ-free mice are protected against disease development. Thus, the gut microbiota has been implicated as a causative, or contributing, factor to obesity, diabetes as well as cardiovascular disease. By using germ-free and conv...

Autoimmune hypophysitis (AH) is characterized by lymphocytic infiltration and eventually destruction of the pituitary tissue. AH accounts for ~1% of pituitary masses and 0.5% of hypopituitarism. Although it has been recognized as an uncommon pituitary disease, its true frequency is not known but certainly underestimated. AH may affect pre- and post-menopausal women, men and children, but most cases are reported in women during reproductive age. AH may be associated with other ...

Introduction: Following extensive research activity to develop an effective hormonal approach to control male fertility, little is known concerning attitudes of men and women towards male contraception in different countries. Although several pharmaceutical companies have conducted studies in male contraception, a full clinical development programme to obtain approval for one of the hormonal methods has never been initiated.Methods: Several studies and s...

The network paradigm is being increasingly used to describe the topology and dynamics of complex systems. The representation of protein structures as networks of interacting amino acids has in fact been used to investigate and elucidate complex phenomena such as protein folding and unfolding, protein stability, the role of structurally and functionally important residues, protein-protein and protein-DNA interactions and intra- and inter-protein communication and allosterism.</...

Adrenal steroid hormones are vitally important. Deficient adrenal steroid biosynthesis causing a lack of glucocorticoid and / or mineralocorticoid hormones leads to hypoglycaemia, hypotension, salt loss and death. Concomitant changes in adrenal androgen biosynthesis are responsible for virilisation in females or under-virilisation in males. Because of the importance of adrenal steroids for overall survival and reproduction, defects in steroidogenesis and steroid action are rar...

Physical activity exerts an important influence on the endocrine system, modulating synthesis and secretion of several hormones. On the other hand, several hormones are able to influence physical performance and body composition. Thus, a two-way relationship between exercise and hormones exists.The use of performance-enhancing compounds dates back to the initial Olympiad in ancient Greece where herbal remedies and animal extracts were used by the athlete...